Prevalence of Mutations in Adenomatous Polyposis and Colorectal Cancer-Associated Genes in Patients with Multiple Colon Polyps Stratified by Age.
•Older patients have a lower likelihood of a mutation in genes that cause adenomatous polyposis (APC, MUTYH, POLE, POLD1, and biallelic MMR mutations (CMMRD)), regardless of the number of polyps that they have.
•Patients with low to moderate polyposis have relatively high mutation frequencies regardless of age in genes associated with increased risk for colorectal cancer, but not necessarily polyposis (MLH1, MSH2, MSH6, PMS2, EPCAM, TP53, CHEK2, CDH1).
•Multigene panel testing including non-polyposis colorectal cancer genes should be considered in older patients with polyposis.