Session # 781

Genetic Predisposition to Invasive Lobular Carcinoma

  • Despite accounting for about 15% of all BCs diagnosed each year, making ILC the second most common histologic subtype after invasive ductal breast cancer (IDC), it is largely underrepresented in genetic studies.
  • Pathogenic alteration frequencies were compared between female ILC and IDC cases, among ~91,000 patients referred for testing, including ~4700 ILC cases
  • Pathogenic alterations were more common in CDH1 in ILC patients while BRCA1 and PALB2 were more common in IDC patients. Other than that, gene-specific pathogenic alterations were similar between ILC and IDC cases referred for MGPT, supporting multigene panel testing when suspecting hereditary cancer predisposition regardless of an ILC vs. IDC diagnosis.

  • Authors: Jill Dolinsky; Eric C. Polley; Jie Na; Brandon Smith; Chunling Hu; Siddhartha Yadav; Holly LaDuca; Fergus J. Couch
  • Collaborators: Mayo Clinic
  • Conference: Miami Breast Cancer Conference 2019
  • Date: Thursday, Mar 07, 2019 6:00pm - 6:30pm

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