Genetic predisposition to invasive lobular carcinoma
Despite accounting for about 15% of all BCs diagnosed each year, making ILC the second most common histologic subtype after invasive ductal breast cancer (IDC), it is largely underrepresented in genetic studies.
Pathogenic alteration frequencies were compared between female ILC and IDC cases, among ~91,000 patients referred for testing, including ~4700 ILC cases
Pathogenic alterations were more common in CDH1 in ILC patients while BRCA1 and PALB2 were more common in IDC patients. Other than that, gene-specific pathogenic alterations were similar between ILC and IDC cases referred for MGPT, supporting multigene panel testing when suspecting hereditary cancer predisposition regardless of an ILC vs. IDC diagnosis.
Authors: Jill Dolinsky; Eric C. Polley; Jie Na; Brandon Smith; Chunling Hu; Siddhartha Yadav; Holly LaDuca; Fergus J. Couch