Session # 64

Reducing Unnecessary Screening in Lynch-Like Syndrome with Tumor Sequencing

  • A simulated case based survey assessed the use of tumor sequencing data in making recommendations for colon and endometrial cancer screening/prevention in suspected Lynch syndrome.
  • Providers often recommend increased screening procedures based on the detection of mismatch repair deficiency by IHC staining, even when no germline MMR mutation has been identified.
  • Knowledge of biallelic somatic mutations in a MMR gene (detected by tumor sequencing) helps to rule out Lynch syndrome and reduces the need for costly high-risk screening and risk reduction procedures.

  • Authors: Virginia Speare; Kyle Allen; Sara Pirzadeh-Miller; Amber Gemmell; Andrea Forman; Leigha Senter; Holly LaDuca; Brigette Tippin Davis; Kory Jasperson
  • Collaborators: Fox Chase Cancer Center; Ohio State University (OSU); The University of Texas
  • Conference: Collaborative Group of the Americas on Inherited Colorectal Cancer (CGA-ICC) 2018
  • Date: Sunday, Oct 14, 2018 5:30pm - 7:00pm

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