Session # 9846

Concordance of Germline Multigene Panel Testing with Prior Microsatellite Instability and Immunohistochemistry Analyses in Endometrial Cancer Patients

  • Nearly half (47%) of all IHC results were discordant with germline MMR gene testing results.
  • The vast majority of these cases had abnormal MSI/IHC with no germline mutation identified.
  • These results may help guide clinicians on what to expect from multigene panel testing in patients with a particular MSI/IHC results and suggest scenarios where somatic mismatch repair gene testing may be useful.

  • Authors: Kory Jasperson; Carin Espenschied; Heather Hampel; Patrick Reineke; Tina Pesaran; Virginia Speare; Jessica Profato; Ian M Frayling
  • Collaborators: Ohio State University (OSU)
  • Conference: Society of Gynecologic Oncology (SGO) 2018
  • Date: Sunday, Mar 25, 2018 3:45pm - 4:45pm

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