Session # 1224, Program Number: PD1-11

Moderate Risk Genes Matter: Multigene Testing for Hereditary Breast Cancer


  • Over 30,000 breast cancer cases were tested, 10.5% were positive for a germline mutation
  • 80.0% of the gene mutations identified (8.4% of all breast cancer patients) occurred in genes with NCCN® management guidelines for at least one cancer type
  • This large cohort indicates that approximately 3.9% and 6.6% of breast cancer patients have mutations in high and moderate risk genes, respectively. Though these values may shift as gene-specific breast cancer risks continue to be refined, it is clear that moderate risk genes play a significant role in breast cancer susceptibility

  • Authors: Michelle Jackson; Holly LaDuca; Jessica Profato; Carin Espenschied
  • Conference: San Antonio Breast Cancer Symposium (SABCS)
  • Date: Wednesday, Dec 06, 2017 5:00pm - 7:00pm

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