Session # 126

Concordance of Multi-Gene Panel Testing with Prior Microsatellite Instability and Immunohistochemistry Analyses.

  • Nearly 25% of MSI and/or IHC results were discordant with germline MMR gene testing results.
  • The vast majority of these had abnormal MSI/IHC with no germline mutation identified.
  • These results may help guide clinicians on what to expect from multigene panel testing in patients with a particular MSI/IHC results and suggest scenarios when somatic mismatch repair gene testing may be useful.

  • Authors: Kory Jasperson; Carin Espenschied; Heather Hampel; Patrick Reineke; Tina Pesaran; Ian M Frayling
  • Conference: Collaborative Group of the Americas on Inherited Colorectal Cancer (CGA-ICC)
  • Date: Friday, Oct 20, 2017 5:30pm - 7:00pm

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