Newborn Screening and Genomics with Robert C. Green, MD, MPH

• The Genomes2People Research Program (G2P), led by Robert Green at Brigham and Women’s Hospital, the Broad Institute, Ariadne Labs, and Harvard Medical School, conducts research to accelerate the implementation of genomic medicine and the promise of precision health. In his talk, "The Path to Universal Newborn Sequencing," Dr. Green discusses the latest advancements in genomics research and the promise it holds for personalized and preventive medicine, drawing on his work leading the MedSeq and BabySeq projects.

  Throughout his talk, Dr. Green highlights the progress made by the MedSeq and BabySeq projects in advancing our understanding of genomics and its application to clinical care. MedSeq explored the use of whole genome sequencing in primary health care and cardiology specialty care, while BabySeq focuses on the use of genomic sequencing as screening in newborns. In its current phase, BabySeq is enrolling 1,000 families from diverse populations and using whole genome sequencing as screening to assess clinical utility and cost effectiveness.

  Dr. Green discusses how the insights gained through these projects are paving the way for a more personalized and preventive approach to medicine. He emphasizes the importance of integrating genomic data into clinical care and the need for policies and guidelines to ensure that this is done in an ethical and responsible manner.

  Through rigorous scientific research, G2P is establishing a foundation of evidence for genomic medicine that will accelerate the adoption of novel genomics-based technologies and hasten the day when illness is not just treated, but prevented.

  Level of Instruction: Intermediate

  

  Only the live session qualifies for CEUs but when possible, we host the recordings on our website and NSGC recommends participants to use their personal email instead of work email addresses to ensure they receive their CEU certificates.

  

  Ambry Genetics is approved as a provider for continuing education program by NSGC and ASCLS P.A.C.E ® Program.

Robert C. Green, MD, MPH | Presenter

Professor of Medicine (Genetics)

Robert Green, MD, MPH is a board-certified medical geneticist and Professor of Medicine at Harvard Medical School who directs the Genomes2People Research Program at Mass General Brigham, Ariadne Labs and the Broad Institute. Dr. Green’s empirical research and policy development is accelerating the implementation of genomic and precision medicine. His work has established the safety and feasibility of disclosing various forms of genetic risk information, assessed the impact of whole genome sequencing in primary care, created the concept of aggregate penetrance of genomic variants in a prospective population cohort and provided early data on the clinical utility and cost-effectiveness of genomic sequencing in healthy adults (the MedSeq Project), and in active duty military personnel (the MilSeq Project). Most recently Dr. Green is leading the first empirical trial of comprehensive sequencing in healthy newborn infants, the NIH-funded BabySeq Project. Dr. Green established the world’s first academically-affiliated, family-oriented Preventive Genomics Clinic in Boston and led policy development for returning genomic information to research participants within the Global Alliance for Genomics and Health, the Verily-Google Baseline Project and All of Us Research Program. In 2017, he co-founded the nationwide telegenetics company Genome Medical.

Rebecca Carr, MS, CGC | Moderator

Oncology Genomic Science Liasion

Rebecca Carr joined Ambry in 2022 as the Oncology Genomic Science Liaison for the Southwest region. She previously worked as a genetic counselor at Banner MD Anderson Cancer Center in Gilbert, Arizona. In her current role, she serves as a clinical liaison for the field team to educate health care providers and key opinion leaders on genetic testing and genomic medicine. Rebecca received her Bachelor's of Science degree in Biochemistry and Molecular and Cellular Biology from the University of Arizona. She earned her Master's of Science degree in Human Genetics and Genetic Counseling from Stanford University and is certified by the American Board of Genetic Counseling.