The field of inherited arrhythmias is rapidly expanding and a growing number of genes have been associated with these diseases. However, the clinical application of genetic testing is challenged by the complexity of interpretation of the majority of variants detected. In addition, recent scientific evidence has been questioning the “one gene one disease concept” adding complexity to the clinical management of these patients. This seminar will review the clinical and genetic features of different inherited arrhythmogenic disorders and how to better target genetic testing in order to improve the interpretation of the results. Finally, the seminar will discuss current translational science strategies that can improve the understanding of genotype phenotype correlations and provide novel therapeutic approaches in these conditions.
Level of Instruction: Advanced