This seminar will focus on updating the audience on recent publications in the prenatal exome sequencing space, including the points to consider for prenatal exome sequencing from ACMG published this year. The technical challenges and diagnostic considerations of performing exome sequencing for fetal indications will be reviewed. This session will also cover diagnostic rates by indication type, including summarizing current data on expanded indications for prenatal exome sequencing referrals like non-structural fetal anomalies and other pregnancy-related findings.