Back to Webinars

The Clinical Impact of TP53 Inclusion in Multi-Gene Panels

Friday, February 8, 2019
1 hour
C.E.U.: 1 Category 1 Contact Hour
P.A.C.E.: 1 Unit

Multi-Gene panel-based genetic testing has emerged as the standard of care for cancer genetic testing.  This has led to the identification of TP53 mutations among individuals without classic personal or family histories of Li-Fraumeni syndrome.    These mutations may be due to mosaicism, clonal hematopoiesis, or due to form fruste Li-Fraumeni syndrome.   We will discuss how these findings are shaping clinical cancer genetics care and how they are leading to a re-evaluation of the epidemiology and penetrance of germline TP53 mutations.   

Explore Our Tests Patient Billing Billing CARE  

Staff Portraits. Huma Rana, M.D.
Huma Rana
Instructor in Medicine
Huma Q. Rana, MD, MPH is the Clinical Director of the Division of Cancer Genetics and Prevention at Dana-Farber Cancer Institute, and Assistant Professor of Medicine at Harvard Medical School.  At Dana-Farber and its regional campuses, Dr. Rana oversees the medical management and the clinical operations that provide care to individuals with genetic susceptibility to […]

Dr. Huma Q. Rana is a physician at Dana Farber Cancer Institute, board certified in Internal Medicine and Clinical Genetics.  She received her medical degree from the Rutgers Robert Wood Johnson Medical School, completed her Internal Medicine and Genetics training at Mount Sinai School of Medicine in New York, and joined Dana-Farber in 2012. 

At Dana-Farber, she is the Clinical Director of the Center for Cancer Genetics and Prevention.  She provides longitudinal medical management of patients with hereditary cancer predispositions, and also leads multiple research projects studying various hereditary cancer syndromes. 

5af33d86ce6be
Brooke Overstreet
Genetic Specialist I
Brooke Overstreet earned her M.S. in Genetic Counseling at the University of Cincinnati and also holds an M.S. in Molecular and Cellular Biology from the University of Arizona. Prior to becoming a genetic specialist at Ambry, she worked as a clinical genetic counselor at Mayo Clinic in Arizona and counseled patients for oncology, neurology, cardiology […]

Brooke Overstreet, MS, CGC received her bachelor’s and master’s degrees in Molecular and Cellular Biology from the University of Arizona. She went on to receive her master’s degree in Genetic Counseling from the University of Cincinnati. Brooke was a clinical genetic counselor at the Mayo Clinic in Arizona for three years where she counseled adult patients for oncology, neurology, cardiology and healthy exome. She joined Ambry in 2017 as an oncology genetic specialist.