This webinar will address the importance of autopsy and post-mortem genetic evaluation in cases of perinatal loss. The process of postmortem evaluation will be summarized, including data about its efficacy at providing answers about the causes of these losses. Reasons for patients’ refusal of postmortem evaluation will be reviewed, including cultural and financial barriers. Alternatives to traditional autopsy will be detailed, including postmortem MRI and the “genetic autopsy”. Finally, a case series of postmortem genetic evaluations will be reviewed.