Breast Cancer Risk Assessment Using the Tyrer-Cuzick Model  with Jack Cuzick, PhD, FRS, CBE 

• This talk will provide a  brief review of the major risk factors for breast cancer and then focus on how they can be combined to create a risk estimate for a woman without breast cancer. The new additions to the Tyrer-Cuzick model will be discussed, notably  mammographic breast density and the use of a polygenic risk score based on a panel of common single nucleotide polymorphisms which individually have a small impact on risk but when used as a panel provide useful discrimination. Analyses based on several large cohorts will be presented to illustrate its use. The talk will close with a review of the potential uses of such a model, both for risk adapted screening strategies and selection of high women most likely to benefit from preventive therapy.

Jack Cuzick, PhD, FRS, CBE | Presenter

      

Jack Cuzick is a director of Wolfson Institute of Preventive Medicine in London and a head of its Centre for Cancer Prevention. He is John Snow Professor of Epidemiology at Queen Mary, University of London. He holds a PhD in Mathematics and has previously worked at Oxford University and Columbia University, New York.  His current interests are in cancer epidemiology and clinical trials, with special interest in prevention and screening. He was awarded CBE in Jan 2017, he is a Fellow of the Royal Society, Academy of Medical Sciences and the Royal Statistical Society.

Sarah Campian, MS, CGC | Moderator

   

Sarah Campian joined Ambry Genetics in 2018 as the Oncology Genetic Specialist for the Great Lakes territory. She previously worked as a clinical genetic counselor at the Grosfeld Cancer Genetics Center at Beaumont Health. Her research interests include Lynch syndrome and identification of gene mutation carriers in minority populations. Sarah received her Bachelors of Science degree in Biology from Saginaw Valley State University. She earned her Masters of Science degree in Genetic Counseling from Wayne State University and is certified by the American Board of Genetic Counseling.