Genome Sequencing in Healthy Individuals: Updates from the MedSeq, BabySeq and PeopleSeq with Robert C. Green, MD, MPH 

  • This presentation will summarize research from the Genomes2People Research Program at Brigham and Women’s Hospital and Harvard Medical School on medical, behavioral and economic outcomes associated with sequencing of apparently healthy individuals.   

   

Robert C. Green, MD, MPH is a medical geneticist and physician-scientist who directs the G2P Research Program (genomes2people.org) in translational genomics and health outcomes as Professor of Medicine in the Division of Genetics at Brigham and Women’s Hospital, the Broad Institute and Harvard Medical School. Dr. Green has been continuously funded by NIH for 26 years and has published over 300 papers. Originally trained as a neurologist and epidemiologist, he contributed for over a decade to the clinical characterization, treatment trial methodology and risk refinement for Alzheimer’s disease. After re-training as a medical geneticist, he conducts empirical research on the medical, behavioral and economic outcomes around the implementation of genomic medicine. Dr. Green led the first NIH-funded trials disclosing common complex disease risk (REVEAL Study) and the first prospective study of direct-to-consumer genetic testing (PGen Study). He currently leads and co-leads the first randomized trials to explore the implementation of medical sequencing in adults (MedSeq Project) and newborns (BabySeq Project). His team recently published the MedSeq Project results assessing medical outcomes, appropriateness of care and downstream medical costs of whole genome sequencing in primary care. With support from the Air Force, and in collaboration with military medicine colleagues, he is conducting the first implementation study of sequencing with return of results in active duty military personnel (MilSeq Project). Dr. Green was lead author on the original recommendations for managing secondary findings in clinical sequencing from the American College of Medical Genetics and Genomics and led the first published demonstration of aggregate penetrance of genomic variants in an unselected population. He is a member of the National Academies of Science, Engineering and Medicine Committee on the “Evidence Base for Genetic Testing” and a Board Member of the Council for Responsible Genetics. He works with the Global Alliance for Genome Health and with the All of Us Research Program on implementation standards for communicating genomic information. In 2014, he won the Coriell Prize for Scientific Achievement in Personalized Medicine.

     

Stephany earned her bachelor’s degree from Purdue University in 2000 and worked in academic research labs for five years before attending graduate school at Arcadia University where she earned her degree in genetic counseling. After graduate school, Stephany worked both pediatric and cancer clinics for Southern California Kaiser Permanente. Stephany joined Ambry Genetics in the beginning of 2012 and is currently a supervisor of the genetic counselor cancer reporting team.

  • Mon, July 16, 2018
  • 12:00pm PDT
  • Duration: 1 hour
  • C.E.U. 1 unit
  • P.A.C.E. 1 unit

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