PARP Inhibitors in 2020: Where Are We Now, and Where Are We Going? with Payal Shah, MD

  • In this webinar, we will review the mechanism of action of PARP inhibitors including the principle of synthetic lethality and the cellular basis for PARP inhibitor activity.  We will then review some of the seminal clinical trials leading to FDA approval of PARP inhibitors in the context of ovarian cancer, metastatic breast cancer, and pancreas cancer.  Finally, we will discuss select clinical trials representative of directions of future PARP inhibitor development.

Assistant Professor of Medicine, University of Pennsylvania

Dr. Payal D. Shah is an Assistant Professor of Medicine in the Division of Hematology / Oncology at the Abramson Cancer Center and the Basser Center for BRCA at the University of Pennsylvania.  She is a medical oncologist and clinical investigator specializing in breast cancer and cancer genetics.  Her work is dedicated to advancing the care of, and developing novel therapeutic strategies for breast cancer patients within and outside of the realm of inherited cancer predispositions. To this end, her research focuses on cancer risk assessment and mitigation, as well as translational therapeutics.  She conducts clinical trials examining targeted therapy and immunotherapy, including novel agents such as PARP inhibitors and CAR T-cells.  She has published findings and has presented her research at major national conferences including annual meetings of ASCO and AACR.  She is the recipient of several awards including a Susan G. Komen Career Catalyst Award, an ASCO Conquer Cancer Foundation Young Investigator Award, and a Basser Young Leadership Council Young Investigator Award.

Sr. Manager, Reporting- Rare Disease, Ambry Genetics

Brissa Martin received her B.S. in Microbiology and Molecular Genetics from the University of California, Los Angeles and her M.S. in Genetic Counseling from the University of California, Irvine. She has worked primarily in the field of molecular diagnostics and has experience in a variety of specialties including neurology, mitochondrial and metabolic disorders, cancer, and whole exome sequencing. She has clinical expertise in pediatric genetics and prenatal diagnosis. Additional experience includes laboratory processes, result reporting, variant assessment, test launching, client services, and sales.

Register Now
  • Wed, February 26, 2020
  • 10:00am PST
  • Duration: 1 hour
  • C.E.U.
    1 Category 1 Contact Hour
  • P.A.C.E. 1 unit

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