Receiving a variant of unknown significance (VUS) result from genetic testing can be challenging. We are committed to offering clinicians clear, accurate, clinically-relevant details about a VUS, to help the patients and families impacted by these results.
Ambry's Variant Assessment and Classification scheme helps bring clarity to genetic testing results by providing:
Variants found through genetic testing are currently classified and reported as follows:
Family Studies Program
Through our Family Studies Program, informative family members of patients found to carry a VUS are eligible for testing for the same alteration. The co-segregation data from these studies can help clarify the clinical significance of a VUS. Complete review of application materials is required prior to approval of family studies. Please visit our Family Studies Program page for details.