Oncology

Session # 1224, Program Number: PD1-11

Moderate Risk Genes Matter: Multigene Testing for Hereditary Breast Cancer

Poster-Discussion

  • Over 30,000 breast cancer cases were tested, 10.5% were positive for a germline mutation
  • 80.0% of the gene mutations identified (8.4% of all breast cancer patients) occurred in genes with NCCN® management guidelines for at least one cancer type
  • This large cohort indicates that approximately 3.9% and 6.6% of breast cancer patients have mutations in high and moderate risk genes, respectively. Though these values may shift as gene-specific breast cancer risks continue to be refined, it is clear that moderate risk genes play a significant role in breast cancer susceptibility

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