Check out the November 2016, Volume #3, Issue #11 of our newsletter.
This gene encodes a carcinoma-associated antigen and is a member of a family that includes at least two type I membrane proteins.
This antigen is expressed on most normal epithelial cells and gastrointestinal carcinomas and functions as a homotypic calcium-independent cell adhesion molecule.
The antigen is being used as a target for immunotherapy treatment of human carcinomas. Mutations in this gene result in congenital tufting enteropathy.