DICER1

Description 
endoribonuclease Dicer; K12H4.8-LIKE; helicase MOI; helicase-moi; Dicer1, Dcr-1 homolog; helicase with RNAse motif; dicer 1, double-stranded RNA-specific endoribonuclease

 

This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus.
 
The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression.
 
Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2010]

 

Aliases 
DCR1; MNG1; Dicer; HERNA
Chromosomal Locations 
14q32.13
Tests 
Pleuropulmonary Blastoma (PPB) Family Tumor and Dysplasia Syndrome, DICER1 Syndrome
DICER1 Genetic Mutation Analysis