Session # Abstract Poster# 289

Discrepancies in payer coverage and practice guidelines for genetic testing of ACMG cardiovascular genes

• The clinical presentations of many inherited cardiovascular (CV) conditions overlap, thereby genetic testing may clarify diagnoses and facilitate appropriate clinical management.
• The ACMG published a guideline for 59 genes with clinical actionability that should be reported if found on exome, of which 30 are related to CV conditions.
• We compared the published practice guidelines for CV genetic testing against the 2018 coverage policies of 4 large US healthcare plans (102 million lives covered) and found that payer coverage is inconsistent and often limited across the CV conditions for the clinically actionable ACMG genes.

• Authors: Nancy Niguidula; Jill Dolinsky; Benjamin Feldmann; Illa Hadzimehmedagic; Greg Nogle; Carrie Horton; Tami Johnston; Heather Zimmermann; Zöe Powis
• Conference: ACMG 2019
• Date: Thursday, Apr 04, 2019 10:00am - 11:30am