Akcea Therapeutics and Ambry Genetics are partnering to offer no-cost, confidential genetic testing and confidential genetic counseling for patients suspected of having or clinically diagnosed with hATTR amyloidosis with polyneuropathy.

hATTR Compass is a no-cost genetic testing program operated solely through Ambry Genetics and sponsored by Akcea Therapeutics. Ambry Genetics does not share any patient identifiable information.

The hATTR Compass Genetic Testing Program is designed to:

  • Help accelerate or confirm the diagnosis of hATTR amyloidosis with polyneuropathy
  • Provide support and resources to patients, caregivers and healthcare professionals throughout the genetic testing process
  • Empower patients and their healthcare professionals to make the most informed decisions about their health care

Who is eligible?

The hATTR Compass Program is available for patients who are 18 years and older and have a family history of hATTR amyloidosis. If there is no family history, the patient must have at least two clinical symptoms or manifestations related to hATTR amyloidosis.

What test is right for your patient?

ATTR Amyloidosis Test

Single-gene test for TTR Select this test to confirm suspected diagnosis


92-gene panel targeting patients with cardiomyopathies, including hATTR amyloidosis Select this test for a comprehensive genetic assessment of your cardiomyopathy patients.


81-gene panel targeting patients with hereditary neuropathies, including hATTR amyloidosis. Select this test for a comprehensive genetic assessment of your neuropathy patients.

Sponsored genetic counseling

Genetic counselors are available at no cost to consult with your patient through pre-test and post-test counseling. Genetic counselors at PWNHealth, the third-party, independent partner working with the hATTR Compass Program, are trained to help patients navigate the social and emotional aspects of genetic testing. During pre-test counseling, a genetic counselor will be available by phone to discuss the benefits, limitations and implications of genetic testing with your patient. During post-test genetic counseling, a genetic counselor will be available by phone to help your patient interpret their results and the potential implications for them and their families. If requested, genetic counselors can review treatment options available and provide additional resources. If your patient is interested in this confidential service, make sure to indicate in the ordering form if your patient would like to have pre-test and/or post-test counseling. If indicated, a customer service representative will contact your patient to schedule the designated counseling session(s).

What is genetic counseling?

How do I enroll my patient?

  1. Order a Sample Kit: Click on Order a Sample Kit button on the right. A custom ordering form will ship with each kit.
  2. Collect Samples: Use the hATTR Compass Genetic Testing Kit provided to you by mail or Ambry representative to collect your patient’s blood or saliva DNA samples. Complete the Test Requisition Form provided with the kit. Tip: Be sure to indicate whether your patient would like to receive confidential genetic counseling on the order form.
  3. Submit for DNA Analysis: Submit the hATTR Compass Kit for DNA analysis with the completed Test Requisition Form using the mailing instructions provided in your kit.
  4. Receive Results: Your patient’s results will be sent to you within 2-4 weeks. Tip: Ambry Genetic Counselors are available to help you interpret the test results. For assistance, contact +1 949-900-5500.
  5. Make a Plan: Work with your patient to make a healthcare management plan based on their test results. Tip: If you’d like to learn more about hATTR amyloidosis, start here www.hATTRGuide.com.

We’re here to help you every step of the way. If you have any questions about the hATTR Compass Program, contact us at +1 949-900-5500.

The hATTR Compass Program is currently available in the United States, Canada and Puerto Rico. While Akcea provides financial support for this program, all tests and services are confidential and performed by independent third parties.

At no time does Akcea receive patient identifiable information.

How to order a test

Submit a paper Test Request Form (TRF)

AmbryPort® (online ordering portal)
Login or create an account

  • Download custom TRF above
  • Complete TRF
  • Collect patient DNA sample (blood or saliva)*
  • Ship the Sample Submission Kit, with the completed TRF, using the pre-paid FedEx envelope
  • Receive your secured report through AmbryPort, fax or e-mail

* You can also send a saliva kit directly to your patient’s home for them to submit their saliva sample. Just check the “Sent kit to patient” box in the TRF. We will ship a kit to your patient as soon as we receive your TRF.

Step 1
Sign Up

Sign up on AmbryPort and start an order by adding a new patient
Click here

Step 2
Enter Code

Enter the partner code
in the Partner Code box on the patient information section

Step 3
Select a Test

Select appropriate test for your patient. Don’t forget to check pre- and/or post-test genetic counseling

Step 4
Review Order

Complete all required fields and authorize eTRF using DocuSign

We’re here to help you every step of the way. If you have any questions about the hATTR Compass Program, contact us at +1 949-900-5500.

Staying connected through Backpack Health

Backpack Health is a mobile and web-based app that helps patients keep track of their symptoms, procedures, diagnostic tests and ongoing treatment for hATTR amyloidosis. The tool also makes it easy for individuals and families navigating the hATTR amyloidosis journey to share important medical information with healthcare professionals. Access to the app is complimentary for patients with hATTR amyloidosis as a part of the hATTR Compass Genetic Testing Program.

Find out the basics about Backpack Health and how it help you on your patient journey here.

Learn more about how you can use Backpack Health to organize and manage your health details and share them with the people who need to know using the user guide here.

Questions about Backpack Health? Get answers to your frequently asked questions about Backpack Health here.

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