Neurology

Is this Brain Tumor Genetic? Assessment and Evaluation for Hereditary Causes of Primary Brain Tumors.

Primary brain tumors are well-known features of several hereditary cancer/tumor predisposition syndromes and have been associated with additional inherited germline mutations as phenotypic spectrums expand and moderately penetrant genes are discovered. Recognizing patterns that should precipitate further evaluation and consideration for hereditary cancer/tumor predisposition syndromes is critical to appropriate clinical management, including differential diagnoses and recommended genetic risk assessment for primary brain tumors.

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