Cardiology

Being diagnosed with a hereditary condition can be scary. That’s why early detection is so important and can make all the difference in the world when it comes to getting in front of a disease.

Know The Basics

More than 1 in 200 people have an inherited cardiovascular condition. Our mission is to identify the condition early so that you, with the help of your clinician, can determine the best treatment and intervention options. Knowing if you have a disease-causing gene mutation not only means better management of the disease, but allows you to help identify others in the family and provide them with powerful life-giving information.

Tests and Gene Information

Click on the disease or category below to see all genes that appear on the test.

  • Arrhythmia
    • RhythmFirst

      A multi gene panel to identify and diagnose common inherited arrhythmias such as long QT syndrome, Brugada syndrome and short QT syndrome. The test can be an effective way to confirm an arrhythmia disorder and direct medical management and treatment decisions.

      Gene List

      AKAP9, ANK2, CACNA1C, CAV3, KCNE1, KCNE2, KCNH2, KCNJ2, KCNQ1, SCN4B, SCN5A, SNTA1

    • RhythmNext

      A multi gene panel to identify and diagnose common inherited arrhythmias such as long QT syndrome, Brugada syndrome and short QT syndrome. The test can be an effective way to confirm an arrhythmia disorder and direct medical management and treatment decisions.

      Gene List

      AKAP9, ANK2, CACNA1C, CACNA2D1, CACNB2, CALM1, CASQ2, CAV3, DSC2, DSG2, DSP, GPD1L, HCN4, JUP, KCND3, KCNE1, KCNE2, KCNE3, KCNH2, KCNJ2, KCNJ8, KCNQ1, LMNA, NKX2-5, PKP2, RYR2, SCN1B, SCN3B, SCN4B, SCN5A, SNTA1, TBX5, TGFB3, TMEM43, TRDN, TRPM4

    • CPVTNext

      A 6 gene panel to identify catecholaminergic polymorphic ventricular tachycardia, an inherited arrhythmia that occurs during the stress of exercise or an onset of emotion.

      Gene List

      ANK2, CALM1, CASQ2, KCNJ2, RYR2, TRDN

    • ARVDNext

      A 9 gene panel that identifies arrhythmogenic right ventricular dysplasia, an inherited disorder characterized by abnormal fat deposits around the wall of the heart. This can cause problems with the electrical system in the heart that controls the heartbeat's regular rhythm.

      Gene List

      DSC2, DSG2, DSP, JUP, LMNA, PKP2, RYR2, TGFB3, TMEM43

  • Cardiomyopathy
    • HCMFirst

      A multi-gene panel that can identify at-risk individuals or confirm a diagnosis of hypertrophic cardiomyopathy (HCM), an enlarged heart muscle disease. Often, HCM can be asymptomatic and sudden death is the first and only symptom.

      Gene List

      MYBPC3, MYH7

    • HCMNext

      A multi-gene panel that can identify at-risk individuals or confirm a diagnosis of hypertrophic cardiomyopathy (HCM), an enlarged heart muscle disease. Often, HCM can be asymptomatic and sudden death is the first and only symptom.

      Gene List

      ACTC1, ACTN2, ANKRD1, CSRP3, FXN, GLA, JPH2, LAMP2, MYBPC3, MYH6, MYH7, MYL2, MYL3, MYOZ2, MYPN, NEXN, PLN, PRKAG2, PTPN11, RAF1, TCAP, TNNC1, TNNI3, TNNT2, TPM1, TTR, VCL

    • DCMNext

      A 36 gene panel that identifies dilated cardiomyopathy, a disease characterized by enlargment of the heart's left ventricle. This can cause problems with the electrical system in the heart that controls the heartbeat's regular rhythm.

      Gene List

      ABCC9, ACTC1, ACTN2, ANKRD1, BAG3, CSRP3, DES, DMD, EYA4, FKTN, LAMA4, LAMP2, LDB3, LMNA, MYBPC3, MYH6, MYH7, MYPN, NEXN, NKX2-5, PLN, RAF1, RBM20, SCN5A, TAZ, TBX20, TCAP, TMPO, TNNC1, TNNI3, TNNT2, TPM1, TTN, TTR, TXNRD2, VCL

    • CMNext

      A multi gene panel that can identify many inherited cardiomyopathies. The 55 gene test can confirm a diagnosis and identify at-risk individuals, allowing for effective treatment and prevention management for the patient and their family.

      Gene List

      ABCC9, ACTC1, ACTN2, ANKRD1, BAG3, CRYAB, CSRP3, DES, DMD, DSC2, DSG2, DSP, EMD, EYA4, FKTN, FXN, GATAD1, GLA, JPH2, JUP, LAMA4, LAMP2, LDB3, LMNA, MYBPC3, MYH6, MYH7, MYL2, MYL3, MYOZ2, MYPN, NEXN, NKX2-5, PKP2, PLN, PRKAG2, PTPN11, RAF1, RBM20, RYR2, SCN5A, TAZ, TBX20, TCAP, TGFB3, TMEM43, TMPO, TNNC1, TNNI3, TNNT2, TPM1, TTR, TXNRD2, VCL

    • ARVDNext

      A 9 gene panel that identifies arrhythmogenic right ventricular dysplasia, an inherited disorder characterized by abnormal fat deposits around the wall of the heart. This can cause problems with the electrical system in the heart that controls the heartbeat's regular rhythm.

      Gene List

      DSC2, DSG2, DSP, JUP, LMNA, PKP2, RYR2, TGFB3, TMEM43

    • LVNCNext

      An 8 gene panel that identifies left ventricular non-compaction, a disease characterized by extra muscle bands and spaces in the wall of the heart. This can cause problems with the electrical system in the heart that controls the heartbeat's regular rhythm.

      Gene List

      ACTC1, LDB3, LMNA, MYBPC3, MYH7, TAZ, TNNT2, TPM1

  • Aortic Aneurysms / Dissections
    • TAADNext

      A next generation sequencing panel that analyzes 22 genes associated with thoracic aortic aneurysms and dissections, Marfan syndrome and related disorders that often contribute to sudden cardiac death. The test can confirm a diagnosis and aid in patient management and treatment options.

      Gene List

      ACTA2, CBS, COL3A1, COL5A1, COL5A2, FBN1, FBN2, FLNA, MED12, MYH11, MYLK, NOTCH1, PLOD1, PRKG1, SKI, SLC2A10, SMAD3, SMAD4, TGFB2, TGFB3, TGFBR1, TGFBR2

    • Ehlers-Danlos syndrome

      A genetic test to identify Ehlers-Danlos syndrome, an inherited connective tissue disorder.

      Gene List

      COL3A1

  • Familial Hypercholesterolemia
    • FHNext

      A next generation sequencing panel that analyzes 4 genes associated with familial hypercholesterolemia, a high cholesterol disorder. The test can help confirm a diagnosis and allow for individualized disease management and treatment.

      Gene List

      APOB, LDLR, LDLRAP1, PCSK9

  • Comprehensive Testing
    • CardioNext

      An 85 gene panel that identifies inherited cardiomyopathies, inherited arrhythmias and other inherited cardiovascular conditions.

      Gene List

      ABCC9, ACTC1, ACTN2, AKAP9, ANK2, ANKRD1, BAG3, CACNA1C, CACNA2D1, CACNB2, CALM1, CASQ2, CAV3, CRYAB, CSRP3, DES, DMD, DSC2, DSG2, DSP, EMD, EYA4, FKTN, FXN, GATA4, GATAD1, GLA, GPD1L, HCN4, JAG1, JPH2, JUP, KCND3, KCNE1, KCNE2, KCNE3, KCNH2, KCNJ2, KCNJ5, KCNJ8, KCNQ1, LAMA4, LAMP2, LDB3, LMNA, MYBPC3, MYH6, MYH7, MYL2, MYL3, MYOZ2, MYPN, NEXN, NKX2-5, PKP2, PLN, PRKAG2, PTPN11, RAF1, RBM20, RYR2, SCN1B, SCN2B, SCN3B, SCN4B, SCN5A, SNTA1, TAZ, TBX1, TBX20, TBX5, TCAP, TGFB3, TMEM43, TMPO, TNNC1, TNNI3, TNNT2, TPM1, TRDN, TRPM4, TTR, TXNRD2, VCL

    • CustomNext-Cardio

      A multi test panel that can analyze up to 106 selectable genes that cause inherited cardiomyopathies, inherited arrhythmias, and other inherited cardiovascular conditions.

      Gene List

      ABCC9, ACTA2, ACTC1, ACTN2, AKAP9, ANK2, ANKRD1, BAG3, CACNA1C, CACNA2D1, CACNB2, CALM1, CASQ2, CAV3, CBS, COL3A1, COL5A1, COL5A2, CRYAB, CSRP3, DES, DMD, DSC2, DSG2, DSP, EMD, EYA4, FBN1, FBN2, FKTN, FLNA, FXN, GATA4, GATAD1, GLA, GPD1L, HCN4, JAG1, JPH2, JUP, KCND3, KCNE1, KCNE2, KCNE3, KCNH2, KCNJ2, KCNJ5, KCNJ8, KCNQ1, LAMA4, LAMP2, LDB3, LMNA, MED12, MYBPC3, MYH11, MYH6, MYH7, MYL2, MYL3, MYLK, MYOZ2, MYPN, NEXN, NKX2-5, NOTCH1, PKP2, PLN, PLOD1, PRKAG2, PRKG1, PTPN11, RAF1, RBM20, RYR2, SCN1B, SCN2B, SCN3B, SCN4B, SCN5A, SKI, SLC2A10, SMAD3, SMAD4, SNTA1, TAZ, TBX1, TBX20, TBX5, TCAP, TGFB2, TGFB3, TGFBR1, TGFBR2, TMEM43, TMPO, TNNC1, TNNI3, TNNT2, TPM1, TRDN, TRPM4, TTN, TTR, TXNRD2, VCL

  • Other
    • CHARGE syndrome

      A genetic test that identifies CHARGE syndrome, a birth defect disorder.

      Gene List

      CHD7

    • Alagille syndrome

      A genetic test that identifies Alagille syndrome, a disorder that can affect the liver, heart, and other parts of the body.  

      Gene List

      JAG1

    • Transthyretin amyloidosis

      A genetic test that identifies transthyretin amyloidosis, a slowly progressive condition characterized by the buildup of abnormal deposits of a protein in the body's organs and tissues. This buildup can cause loss of sensation in the extremities. 

      Gene List

      TTR

    • PCDNext

      A genetic test that identifies primary ciliary dyskinesia, a disorder that causes defects in the action of cilia lining the respiratory tract.

      Gene List

      ARMC4, CCDC103, CCDC114, CCDC39, CCDC40, CFTR, DNAAF1, DNAAF2, DNAAF3, DNAAF5, DNAH11, DNAH5, DNAI1, DNAI2, LRRC6, NME8, OFD1, RPGR, RSPH4A, RSPH9, SPAG1

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