Cancer

Being diagnosed with a hereditary condition can be scary. That’s why early detection is so important and can make all the difference in the world when it comes to getting in front of a disease.

Types of Cancer

Sporadic Cancer
Happens by chance in one or two related family members, typically at older ages
Familial Cancer
A clustering of cancer in a family that may be due to genes and/or other shared factors, such as environment and lifestyle
Hereditary Cancer
A clustering of cancer in a family due to inherited gene changes (mutations), which can be passed from parent to child

About Hereditary Cancer

Many people have a family history of cancer, but only 5-10% of cancer is hereditary.

People who have these gene mutations are born with them - they do not develop over time.

Learning if you have an inherited mutation can help you know more about your cancer risks.

People with a higher chance of developing cancer may need screening, like mammograms, that start at younger ages, and occur more often.

Traditionally, many inherited conditions such as cancer, were treated with a ‘one-size-fits-all’ approach. But through our innovative genetic testing and ongoing research we now know that patient outcomes and quality life are dramatically improved with a more personalized approach.

Tests and Gene Information

Click on the disease or category below to see all genes that appear on the test.

  • Breast
    • BRCA1/BRCA2

      Genetic testing for hereditary breast and ovarian cancer 

      Gene List

      BRCA1, BRCA2

    • BRCAplus

      A 6 gene test for hereditary breast cancer, including genes linked to a higher chance to develop breast, ovarian, and/or other cancers

      Gene List

      BRCA1, BRCA2, CDH1, PALB2, PTEN, TP53

    • BRCAplus-Expanded

      An 8 gene test for hereditary breast cancer, including genes linked to a higher chance to develop breast, ovarian, and/or other cancers

      Gene List

      ATM, BRCA1, BRCA2, CDH1, CHEK2, PALB2, PTEN, TP53

    • BreastNext

      A 17 gene, comprehensive test for hereditary breast cancer, including genes linked to a higher chance to develop breast, ovarian, and/or other cancers

      Gene List

      ATM, BARD1, BRCA1, BRCA2, BRIP1, CDH1, CHEK2, MRE11A, MUTYH, NBN, NF1, PALB2, PTEN, RAD50, RAD51C, RAD51D, TP53

    • CancerNext

      Testing for hereditary cancer, including genes linked to a higher chance to develop breast, ovarian, colorectal, uterine, prostate, and/or other cancers

      Gene List

      APC, ATM, BARD1, BMPR1A, BRCA1, BRCA2, BRIP1, CDH1, CDK4, CDKN2A, CHEK2, DICER1, EPCAM, GREM1, HOXB13, MLH1, MRE11A, MSH2, MSH6, MUTYH, NBN, NF1, PALB2, PMS2, POLD1, POLE, PTEN, RAD50, RAD51C, RAD51D, SMAD4, SMARCA4, STK11, TP53

  • Gastrointestinal
    • Lynch syndrome

      Testing for Lynch syndrome, a hereditary colorectal and uterine cancer condition 

      Gene List

      EPCAM, MLH1, MSH2, MSH6, PMS2

    • ColoNext

      Testing for hereditary colon cancer, including genes linked to a higher chance to develop colon polyps, colon and/or other cancers 

      Gene List

      APC, BMPR1A, CDH1, CHEK2, EPCAM, GREM1, MLH1, MSH2, MSH6, MUTYH, PMS2, POLD1, POLE, PTEN, SMAD4, STK11, TP53

    • PancNext

      Testing for hereditary pancreatic cancer, including genes linked to a higher chance to develop pancreatic and/or other cancers

      Gene List

      APC, ATM, BRCA1, BRCA2, CDKN2A, EPCAM, MLH1, MSH2, MSH6, PALB2, PMS2, STK11, TP53

    • CancerNext

      Testing for hereditary cancer, including genes linked to a higher chance to develop breast, ovarian, colorectal, uterine, prostate, and/or other cancers

      Gene List

      APC, ATM, BARD1, BMPR1A, BRCA1, BRCA2, BRIP1, CDH1, CDK4, CDKN2A, CHEK2, DICER1, EPCAM, GREM1, HOXB13, MLH1, MRE11A, MSH2, MSH6, MUTYH, NBN, NF1, PALB2, PMS2, POLD1, POLE, PTEN, RAD50, RAD51C, RAD51D, SMAD4, SMARCA4, STK11, TP53

  • Gynecologic
    • BRCA1/BRCA2

      Genetic testing for hereditary breast and ovarian cancer 

      Gene List

      BRCA1, BRCA2

    • Lynch syndrome

      Testing for Lynch syndrome, a hereditary colorectal and uterine cancer condition 

      Gene List

      EPCAM, MLH1, MSH2, MSH6, PMS2

    • GYNplus

      A 13 gene test for hereditary gynecologic cancer, including genes linked to a chance to develop ovarian, uterine, and/or other cancers

      Gene List

      BRCA1, BRCA2, BRIP1, EPCAM, MLH1, MSH2, MSH6, PALB2, PMS2, PTEN, RAD51C, RAD51D, TP53

    • OvaNext

      A 25 gene test for hereditary gynecologic cancer, including genes linked to a higher chance to develop ovarian, uterine, breast, and/or other cancers

      Gene List

      ATM, BARD1, BRCA1, BRCA2, BRIP1, CDH1, CHEK2, DICER1, EPCAM, MLH1, MRE11A, MSH2, MSH6, MUTYH, NBN, NF1, PALB2, PMS2, PTEN, RAD50, RAD51C, RAD51D, SMARCA4, STK11, TP53

    • CancerNext

      Testing for hereditary cancer, including genes linked to a higher chance to develop breast, ovarian, colorectal, uterine, prostate, and/or other cancers

      Gene List

      APC, ATM, BARD1, BMPR1A, BRCA1, BRCA2, BRIP1, CDH1, CDK4, CDKN2A, CHEK2, DICER1, EPCAM, GREM1, HOXB13, MLH1, MRE11A, MSH2, MSH6, MUTYH, NBN, NF1, PALB2, PMS2, POLD1, POLE, PTEN, RAD50, RAD51C, RAD51D, SMAD4, SMARCA4, STK11, TP53

  • Prostate
    • BRCA1/BRCA2

      Testing for hereditary prostate cancer, including genes linked to a higher chance to develop prostate and/or other cancers

      Gene List

      ATM, BRCA1, BRCA2, CHEK2, EPCAM, HOXB13, MLH1, MSH2, MSH6, NBN, PALB2, PMS2, RAD51D, TP53

    • Lynch syndrome

      Testing for Lynch syndrome, a hereditary colorectal and uterine cancer condition 

      Gene List

      EPCAM, MLH1, MSH2, MSH6, PMS2

    • ProstateNext

      Testing for hereditary prostate cancer, including genes linked to a higher chance to develop prostate and/or other cancers

      Gene List

      ATM, BRCA1, BRCA2, CHEK2, EPCAM, HOXB13, MLH1, MSH2, MSH6, NBN, PALB2, PMS2, RAD51D, TP53

    • CancerNext

      Testing for hereditary cancer, including genes linked to a higher chance to develop breast, ovarian, colorectal, uterine, prostate, and/or other cancers

      Gene List

      APC, ATM, BARD1, BMPR1A, BRCA1, BRCA2, BRIP1, CDH1, CDK4, CDKN2A, CHEK2, DICER1, EPCAM, GREM1, HOXB13, MLH1, MRE11A, MSH2, MSH6, MUTYH, NBN, NF1, PALB2, PMS2, POLD1, POLE, PTEN, RAD50, RAD51C, RAD51D, SMAD4, SMARCA4, STK11, TP53

  • Other
    • BrainTumorNext

      Testing for hereditary brain tumors, including genes linked to a higher chance to develop different types of brain tumors and/or other cancers

      Gene List

      AIP, ALK, APC, CDKN1B, CDKN2A, DICER1, MEN1, MLH1, MSH2, MSH6, NBN, NF1, NF2, PHOX2B, PMS2, POT1, PRKAR1A, PTCH1, PTEN, SMARCA4, SMARCB1, SMARCE1, SUFU, TP53, TSC1, TSC2, VHL

    • MelanomaNext

      Testing for hereditary melanoma, including genes linked to a higher chance to develop melanoma (skin cancer) and/or other cancers

      Gene List

      BAP1, BRCA2, CDK4, CDKN2A, MITF, PTEN, RB1, TP53

    • PancNext

      Testing for hereditary pancreatic cancer, including genes linked to a higher chance to develop pancreatic and/or other cancers

      Gene List

      APC, ATM, BRCA1, BRCA2, CDKN2A, EPCAM, MLH1, MSH2, MSH6, PALB2, PMS2, STK11, TP53

    • PGLNext

      Testing for hereditary endocrine cancers, including genes linked to a higher chance to develop rare tumors known as paragangliomoas and/or pheochromocytomas 

      Gene List

      FH, MAX, MEN1, NF1, RET, SDHA, SDHAF2, SDHB, SDHC, SDHD, TMEM127, VHL

    • RenalNext

      Testing for hereditary kidney (renal) cancer, including genes linked to a higher chance to develop kidney and/or other cancers

      Gene List

      BAP1, EPCAM, FH, FLCN, MET, MITF, MLH1, MSH2, MSH6, PMS2, PTEN, SDHA, SDHB, SDHC, SDHD, TP53, TSC1, TSC2, VHL

  • Comprehensive
    • CancerNext

      Testing for hereditary cancer, including genes linked to a higher chance to develop breast, ovarian, colorectal, uterine, prostate, and/or other cancers

      Gene List

      APC, ATM, BARD1, BMPR1A, BRCA1, BRCA2, BRIP1, CDH1, CDK4, CDKN2A, CHEK2, DICER1, EPCAM, GREM1, HOXB13, MLH1, MRE11A, MSH2, MSH6, MUTYH, NBN, NF1, PALB2, PMS2, POLD1, POLE, PTEN, RAD50, RAD51C, RAD51D, SMAD4, SMARCA4, STK11, TP53

    • CancerNext-Expanded

      Testing for hereditary cancer, including genes linked to a higher chance to develop one or more of the following: brain tumors, breast, colon, ovarian, pancreatic, prostate, kidney, uterine, and/or other cancers.

      Gene List

      AIP, ALK, APC, ATM, BAP1, BARD1, BLM, BMPR1A, BRCA1, BRCA2, BRIP1, CDH1, CDK4, CDKN1B, CDKN2A, CHEK2, DICER1, EPCAM, FANCC, FH, FLCN, GALNT12, GREM1, HOXB13, MAX, MEN1, MET, MITF, MLH1, MRE11A, MSH2, MSH6, MUTYH, NBN, NF1, NF2, PALB2, PHOX2B, PMS2, POLD1, POLE, POT1, PRKAR1A, PTCH1, PTEN, RAD50, RAD51C, RAD51D, RB1, RET, SDHA, SDHAF2, SDHB, SDHC, SDHD, SMAD4, SMARCA4, SMARCB1, SMARCE1, STK11, SUFU, TMEM127, TP53, TSC1, TSC2, VHL, XRCC2

    • CustomNext-Cancer

      Testing for hereditary cancer, including genes linked to a higher chance to develop one or more of the following: brain tumors, breast, colon, ovarian, pancreatic, prostate, kidney, uterine, and/or other cancers.

      Gene List

      AIP, ALK, APC, ATM, BAP1, BARD1, BLM, BMPR1A, BRCA1, BRCA2, BRIP1, CDH1, CDK4, CDKN1B, CDKN2A, CHEK2, DICER1, EPCAM, FANCC, FH, FLCN, GALNT12, GREM1, HOXB13, MAX, MEN1, MET, MITF, MLH1, MRE11A, MSH2, MSH6, MUTYH, NBN, NF1, NF2, PALB2, PHOX2B, PMS2, POLD1, POLE, POT1, PRKAR1A, PTCH1, PTEN, RAD50, RAD51C, RAD51D, RB1, RET, SDHA, SDHAF2, SDHB, SDHC, SDHD, SMAD4, SMARCA4, SMARCB1, SMARCE1, STK11, SUFU, TMEM127, TP53, TSC1, TSC2, VHL, XRCC2

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