Check out the June 2016, Volume #3, Issue #6 of our newsletter.
MYH7 (NM_000257.2) encodes beta myosin heavy chain, a subunit of the hexameric cardiac muscle myosin protein. Cardiac muscle myosin functions as part of the sarcomere to generate the mechanical force required for muscle contraction. The MYH7 gene is located at 14q11.2-q12 and is composed of 38 coding exons. Mutations in MYH7 account for 5-8% of dilated cardiomyopathy, and approximately 40% of hypertrophic cardiomyopathy. In addition, mutations in MYH7 can cause left ventricular non-compaction and skeletal myopathies with and without cardiac involvement (Hershberger et al. Circ Heart Fail. 2009;253-261; Walsh et al. Cardiology. 2010;115:49–60).