BRIP1

BRIP1 (BRCA1 associated C-terminal helicase-1) has been described as a DNA-Dependent ATPase which has been associated with early-onset breast cancer.  Co-localization studies demonstrate that BRIP1 and BRCA1 complexes are responsible for repairing double stranded breaks preventing chromosomal instability. 

Mutations in these genes confer an increase in breast cancer risk, and mutations have been reported in at least 1 person with a history of ovarian cancer to date.

 

 

Aliases 
BACH1
FANCJ
Chromosomal Locations 
17q23.2
An alteration in this gene was identified in a patient who underwent diagnostic exome sequencing at Ambry Genetics.