Please be on the look out for
Ambry Representatives at :
ASCO Breast Cancer Symposium 2014
Enhancing Clinical Care Through Collaboration
San Francisco, CA
09/4/14 - 09/6/14
BRIP1 (BRCA1 associated C-terminal helicase-1) has been described as a DNA-Dependent ATPase which has been associated with early-onset breast cancer. Co-localization studies demonstrate that BRIP1 and BRCA1 complexes are responsible for repairing double stranded breaks preventing chromosomal instability.
Mutations in these genes confer an increase in breast cancer risk, and mutations have been reported in at least 1 person with a history of ovarian cancer to date.